TEK anticorps

N° du produit ABIN1589701

Cet anticorps Souris Monoclonal détecte spécifiquement TEK dans WB, ELISA et FACS. Il présente une réactivité envers Humain et a été mentionné dans 1 publication.

Aperçu rapide pour TEK anticorps (ABIN1589701)

Antigène: TEK (TEK Tyrosine Kinase, Endothelial (TEK))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp TEK est non-conjugé

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS)

Clone: Tek16

Détail du produit anti-TEK anticorps

Fonction: TIE-2 antibody

Specificité: Recombinant human soluble extracellular TIE-2

Attributs du produit: Chromosomal location: 9p21
The monoclonal antibody was produced with the help of BALB/c mice using recombinant human soluble extracellular TIE-2 as the immunizing antigen.

Purification: Mouse IgG1 antibody (#tek16) from hybridomas was purified from cell culture supernatant by Protein G chromatography.

Immunogène: Recombinant human soluble extracellular TIE-2

Isotype: IgG1

Information d'application

Indications d'application: ELISA: Use at 1-2 μg/mL. Western blotting: Use at 2-5 μg/mL. FACS analysis: Use at 2-5 μg/mL.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Centrifuge vial prior to opening. Reconstitute in sterile water to a concentration of 0.1-1.0 mg/mL.

Buffer: PBS

Conseil sur la manipulation: Centrifuge vial prior to opening.

Stock: 4 °C,-20 °C

Stockage commentaire: The lyophilized antibody is stable for at least 2 years at -20°C. After sterile reconstitution the antibody is stable at 2-8°C for up to 6 months. Frozen aliquots are stable for at least 6 months when stored at -20°C. Addition of a carrier protein or 50% glycerol is recommended for frozen aliquots.

Date de péremption: 24 months

Références pour anticorps anti-TEK (ABIN1589701)

Shahani, Covens, Lavendhomme, Jazouli, Sokal, Peerlinck, Jacquemin: "Human liver sinusoidal endothelial cells but not hepatocytes contain factor VIII." dans: Journal of thrombosis and haemostasis : JTH, Vol. 12, Issue 1, pp. 36-42, (2014) (PubMed).

Détails sur TEK

Antigène: TEK (TEK Tyrosine Kinase, Endothelial (TEK))

Autre désignation: TIE-2

Sujet: TEK, TIE2, VMCM, TIE-2, VMCM1, CD202B,Tie-1/Tie and Tie-2/Tek are receptor tyrosine kinases with unique structural characteristics including two immunoglobulin-like domains flanking three epidermal growth factor (EGF)-like domains, followed by three fibronectin type III-like repeats in the extracellular region, and a split tyrosine kinase domain in the cytoplasmic region. Tie-2 is involved in vascular stabilization and remodeling. Although less well understood, Tie-1 may also act as an ANG receptor, possibly in complex with Tie-2. Human Tie-2 cDNA encodes a 1124 amino acid (aa) residue precursor protein with an 18 residue putative signal peptide, a 727 residue extracellular domain and a 354 residue cytoplasmic domain. Tie-2 is a receptor for the angiopoietin (ANG) family: ANG-1, ANG-2, and ANG-3 (mouse)/-4 (human). Ang-2 has been reported to act as an antagonist for Ang-1. Mice engineered to overexpress Ang-2 or to lack Ang-1 or Tie-2 display similar angiogenesis defects.

ID gène: 7010

NCBI Accession: NM_000459, NP_000450

UniProt: Q02763

Pathways: Signalisation RTK, Growth Factor Binding